Pharmaco-metabonomic profiling as a predictor of toxicity in patients with inoperable colorectal cancer treated with capecitabine Authors:
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چکیده
Pharmaco-metabonomic profiling as a predictor of toxicity in patients with inoperable colorectal cancer treated with capecitabine Authors: Alexandra Backshall, Rohini Sharma, Stephen J. Clarke, Hector C. Keun Biomolecular Medicine, Dept of Surgery & Cancer, Faculty of Medicine, Imperial College London South Kensington Campus, Exhibition Rd, London SW7 2AZ, UK Division of Investigative Sciences, Imperial College London Hammersmith Campus, Du Cane Road, London W12 ONN, UK Department of Medical Oncology, University of Sydney Concord Hospital, Concord, Sydney, NSW2137, Australia
منابع مشابه
Predictive Biomarkers and Personalized Medicine Pharmacometabonomic Profiling as a Predictor of Toxicity in Patients with Inoperable Colorectal Cancer Treated with Capecitabine
Purpose: Endogenous metabolic profiles have been shown to predict the fate and toxicity of drugs such as acetaminophen in healthy individuals. However, the clinical utility of metabonomics in oncology remains to be defined. We aimed to evaluate the effect of pretreatment serum metabolic profiles generated by H NMR spectroscopy on toxicity in patients with inoperable colorectal cancer receiving ...
متن کاملPharmacometabonomic profiling as a predictor of toxicity in patients with inoperable colorectal cancer treated with capecitabine.
PURPOSE Endogenous metabolic profiles have been shown to predict the fate and toxicity of drugs such as acetaminophen in healthy individuals. However, the clinical utility of metabonomics in oncology remains to be defined. We aimed to evaluate the effect of pretreatment serum metabolic profiles generated by (1)H NMR spectroscopy on toxicity in patients with inoperable colorectal cancer receivin...
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